Regulate Metabolic Pathways and Hormones

Several mediators are thought to signal the pancreatic Beta cells to respond to insulin resistance. These potential signaling mediators include glucose, free fatty acids, autonomic nerves, fat-derived hormones (Adiponectin), and the gut hormone glucagon like peptide-1 (GLP-1). GLP-1 is an incretin hormone that stimulates insulin secretion, causes Beta cell mitosis while inhibiting apoptosis, inhibits glucagon secretion, and delays gastric emptying with overall anti-diabetic effects.

Leptin and Ghrelin are 2 hormones that have a major influence on energy balance. Leptin is a long-term regulator of energy balance, suppressing food intake and thereby inducing weight loss. Ghrelin is a fast-acting hormone, seemingly playing a role in meal initiation. Thyroid hormone plays a very important role in energy expenditure. They are all interconnected via complex signaling pathways. It is becoming more and more evident that proper diet, exercise, clean environment and stress reduction are the fundamental requirements for a healthy life. Advancements in medical science are slowly unraveling the complex interactions; however we are closer to a clear understanding of the complex interactions or finding a cure.

The ingredients of Cresvin Beta are meant to assist Diabetics in their fight against diabetes; under the supervision of a Diabetologist. The scientific team at Apex Laboratories Private Limited has designed Cresvin Beta for improving the functioning of the metabolic pathways and favourably altering the hormone levels; in an attempt to prevent Diabetes and also aim for remission whenever it is possible. The chances of remission are greatly increased if the various interventions are done at an early stage there are sufficient reserves of functional Beta Cells.

Some of enzymes in the metabolic pathway also play a very important role in the pathogenesis of Diabetes. The ingredients in Cresvin Beta are known to regulate these enzymes, in addition to the hormones.

One of the major anti diabetic herbal in Cresvin Beta is Pterocarpus marsupium. It has been proven as an effective anti diabetic in Indian trials [28, 33]. It has a holistic range of actions, but here we focus on the enzymes and the hormones which are dysregulated in Diabetes.

Pterocarpus has the following beneficial effects:

  • Inhibits Amylase to reduce absorption of Glucose from the gut [8]
  • Inhibits Alpha Glucosidase to reduce glycogenolysis [8]
  • Inhibits Aldose Reductase and reduces intracellular Sorbitol via the Polyol Pathway [41]
  • Shows potent insulinotrophic and insulin-like properties [8].
  • Shares a common signaling pathway with Insulin [8].
  • Increase GLUT4 expression comparable with those of Insulin and
  • Rosiglitazone [8].
  • Increases glycogen synthesis by restoring the level of glycogen synthase [8].
  • Improves GLP-1 to reduce PPHG-Post Prandial Hyper Glycemia in 86% (out of 172) patients [28].

 

Resveratrol improves GLP-1 to reduce PPHG-Post Prandial Hyper Glycemia Resveratrol treatment for 5 weeks is associated with increased circulating levels of GLP-1 and insulin and enhanced levels of intestinal proglucagon mRNA transcripts. Consistent with these findings, Resveratrol combined with a Dipeptidyl peptidase (DPP-4) inhibitor(Sitagliptin) augments portal GLP-1 concentrations and further improves glucose homeostasis [42].

Resveratrol supplementation suppresses postprandial Glucagon responses, which may represent a novel protective mechanism against the development of disturbed glucose tolerance and Type 2 diabetes [43].

Salacia extracts modulate multiple targets that influence carbohydrate and lipid metabolism including α-glucosidase, aldose reductase, pancreatic lipase, PPAR alpha and GLUT-4 mediated glucose uptake. In human studies, Salacia extracts have been shown to decrease plasma glucose and insulin levels, decrease HbA1c, and modulate serum lipid levels with no adverse effects being reported [44].

Gymnema augments glucose uptake and ameliorates insulin resistance by upregulating GLUT-4, PPAR gamma, adiponectin, and leptin levels [40].

Resveratrol increases Adiponectin the “anti obesity hormone” by 9.6% in 1 year [45] “The resveratrol-containing grape extract group showed an increase of the anti-inflammatory serum adiponectin (9.6 %, p00.01) and a decrease of the thrombogenic plasminogen activator inhibitor type 1 (PAI-1) (−18.6 %, p00.05). In addition, 6 key inflammation-related transcription factors were predicted to be significantly activated or inhibited, with 27 extracellular-space acting genes involved in inflammation, cell migration and T-cell interaction signals presenting downregulation (p<0.05) in PBMCs. No adverse effects were detected in relation to the study products.”

Resveratrol has ability to restore Thyroid Hormone (T3) levels [46].Resveratrol also influences thyroid function by enhancing iodide trapping and, by increasing TSH secretion via activation of sirtuins [47].

Withania somnifera or Ashwagandha increases serum T4 levels [48]

In general, consumption of dietary polyphenols has beneficial effects including reducing blood glucose levels and improving insulin sensitivity in metabolic syndrome, type-2 diabetes, and obesity. Some polyphenols clearly appear to have the potential to modulate neuropeptides involved in food intake and satiety [7].

As mentioned above, the natural ingredients (in Cresvin Beta) have significant actions in regulating metabolic pathways and hormones. In combination they have a synergistic action. This could go a long way in reducing the morbidity of Diabetes and various life style diseases.

The Prevention and Remission of Diabetes – PROD Initiative is a holistic approach, laying greater emphasis on improvement of beta cell mass and function; through diet, exercises and reduction of mental stress, in addition to medication as advised by the Physician.

Please go to the Reference Articles.

Disclaimer: Cresvin Beta Team has taken maximum care to ensure that the information is authentic. The information has been extracted from published medical trials and text books. The information is not meant to substitute a Physicians advice, nor is it meant to treat any disease. Members are advised to consult a Physician, Dietician, Physiotherapist or Trainer before taking medication or commencing an exercise program.

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